Bacterial antimicrobial resistance is a hot topic in the world. The emergence of antimicrobial resistance of pathogenic bacteria in aquatic animals and its impact on aquaculture, human and environment are lagging behind, which is easy to be ignored. This paper analyzes the meaning, pollution status, production mechanism, harm and prevention methods of antimicrobial-resistant pathogens in aquaculture, in order to attract the attention of the industry.[Chinese Fishery Quality and Standards,2023,13(5):39-45]