Norovirus (NoVs) is the main pathogens of non-bacterial acute gastroenteritis in humans, the shellfish is the main vector of NoVs transmission, and consumption of NOVs-contaminated shellfish can easily cause food-borne diseases which leads to food safety problems. Studies have shown that there are NoVs receptors similar to human tissue blood group antigens in shellfish, which are easy to bind to norovirus, and it is difficult to remove NoVs from shellfish by conventional purification processing methods. In this paper, the accumulation of NoVs in shellfish, the distribution and seasonality of NoVs, and the binding mechanism of NoVs and shellfish were collected and sorted out. The descriptive characteristics of NoVs in shellfish were summarized, and the latest progress of NoVs elimination control in shellfish was reviewed, aiming at establishing an effective and feasible elimination control technology of NoVs in shellfish, which ultimately provides a support for ensuring the shellfish consumption safety for consumers. [Chinese Fishery Quality and Standards, 2023, 13(3): 53-59]