Pharmacokinetic-pharmacodynamic modeling (PK/PD modeling), which was used to study the variation of the pharmacological effects with time. The model is a scientific tool to help developers select a rational dosage regimen, and is widely used to optimize dosage regimens of antibacterial. The basic theory, research models of PK-PD model and the progress of application of PK-PD model in antibacterial, especially in aquaculture antimicrobial drugs, were summarized, and the theoretical basis to scientific development of the antibiotic regimen for aquaculture was further clarified in this review.