The growth performance and the anti-hypoxic capacity of Jian carp (Cyprinus carpio var. Jian) and Channel catfish (Ietalurus Punetaus) fed with feedstuff in different doses (50 mg/kg、75 mg/kg and 100 mg/kg) of quinocetone for 60 d were investigated under the condition of pond culture. The results showd that the growth rate was increased, and mortality rate and feed coefficient was decreased when compared with the control group. The growth performance at the dose of 75 mg/kg group is better than the other dose groups (50 mg/kg and 100 mg/kg). Growth rates of Jian carp and Channel catfish of quinocetone groups were significantly higher than that of the control group (P<0.05), and the feed coefficient of quinocetone groups was significantly lower than that of the control group (P<0.05). Jian carp and Channel catfish of quinocetone groups were higher survival rates than those of the control group (P<0.05). However, anti-hypoxic capacity and the level of blood cells and hemoglobin of Jian carp (Cyprinus carpio var. Jian) and channel catfish (Ietalurus Punetaus) had no significant differences between 75 mg/kg dosage group and control group (P>0.05). Therefore, the growth rate was shown non-dose-dependently when they were feeded with quinocetone; in addition, anti-hypoxic capacity had no significant effect with or without 75 mg/kg quinocetone. Thus, 75 mg/kg quinocetone was recommended for aquaculture.