As a representative of tlie new type of quinoxalines which are known as a group of synthetic antimicrobial， mequindox and quinocetone    have such   advantages as    low    toxicity，no   accumulative   toxicity    and no residue     and   safe use while maintaining   the   antibacterial.   This   article mainly  summarized  the    effectiveness   and safety  of mequindox    and quinocetone in Apostichopus japonicas    and the status quo of     tlie    research  on  the  residue elimination of active   compound and its  metabolite  in the Apostichopus    japonicas.   It  provided    reference      for  the    reasonable and safe       use      of t!iis    type    of medicines in the aquaculture. [ Chinese Fishery Quality and Standards，2015，5 (3 ):70 -76 ]