In recent years，excessive drug residues caused by illegal drug use have led to the occurrence of aquatic product quality and safety issues and have attracted widespread attention now. Quinolones are widely used to prevent and control  diseases in the aquaculture industry because of its characteristics of wide antimicrobial spectrum，strong antibacterial power，easy absorption，and long half - life. This  paper   summarized  the  physicochemical properties，chemical structure effect and the withdrawal period under different maximum residue levels of quinolones，and focused on the meaning and the influence factors of pharmacokinetic  parameters   in    diferent  processes，in which the   parameters involved in peak time，peak concentration，the apparent volume of distribution，elimination half - life，and clearance rate and  so on. The paper put forward the working ideas，such as strengthening the research    on the residue detection methods of quinolones in aquatic products and establishing the aquatic animal physiologically     based  pharmacokinetic model，witli the aim of providing a reference  and guidance for tlie   scientific  use and regulation    of quinolones  in  the  aquaculture industry. [ Chinese Fishery Quality and Standards，2015，5 (3 ): 13 - 19 ]