Abstract: This paper was to evaluate health risk of arsenic from dietary exposure based on the newest JECFA report（72^rd）. Considering all informations related to the toxicology and epidemiology, exposure assessment, including biomarker studies, analytical methodology, speciation and occurrence in food and drinking-water, a comprehensive evaluation on the toxicity of inorganic As and other arsenic compounds was proposed and the PTWI for inorganic  arsenic.was re-evaluated and reviewed. The lowest calculated BMDL was 3.0 μg/kg b.w. per day for a 0.5% increased incidence of lung cancer above background over the average 11.5 years of follow-up, based on average estimates of the exposure. A sensitivity analysis to investigate the impact of uncertainty in the exposure estimate in this study indicated that this BMDL0.5 could be in the range of 2.0–7.0 μg/kg b.w. per day. The Committee noted that the PTWI of 15 μg/kg b.w. （2.1 μg/kg b.w. per day）advanced at the thirty-third meeting （1988）is in the region of the BMDL_0.5 and therefore was no longer appropriate and the Committee withdrew the previous PTWI. [Chinese Fishery Quality and Standards, 2012, 2(4):000-000]