It has been highly concerned if the heavy metals content in aquatic products exceed the national food security standard. Currently, the traditional analytical techniques which used for heavy metals content detection rely on huge instrument, high cost and complicated operation. Thus, it is urgent to develop new rapid heavy metals detection methods which should be easily handled, cost effective and having good precision. In recent years, electrochemical biosensor is a hot research field of rapid detection of heavy metals, and it is also one of the most important frontier research fields in rapid detection method. Now, it is widely reported that electrochemical biosensors are used for on-site detection of heavy metals in water sample, but their use for heavy metals detection in aquatic products is rarely reported. This review summarized the current development and research progress in heavy metals detection using electrochemical biosensors both at home and abroad, which may provide reference for researchers who work in rapid detection method for heavy metals in aquatic products.